Description
Position Overview:
We are seeking a dynamic and experienced individual, with strong multitasking skills to support our ongoing drug discovery and development programs. The person will lead PK/ADME/Clin Pharm for the various CORE oncology programs at various stages.
Key Responsibilities:
-Work with our internal/external teams (CROs) to support various PK/ADME needs for discovery programs, including:
-Design suitable PK studies for ongoing discovery programs to advance from Hit-to-lead and lead optimization
-Decipher ADME and metabolism profile to help med chem to design and advance programs at various stages
-Help to characterize lead candidates with preferred PK/ADME profile based on their chemical and pharmacology properties
-Use various animal PK/PD data and modeling, to project potential clinical dose range and translational strategy
-Collaborate closely with medicinal chemistry, biology, pharmacology and toxicology for IND enabling studies and regulatory submissions
-Work with our teams, especially our clinical team, for various clinical needs
-Maintain high standards of data quality, documentation, and scientific rigor
Benefits:
-Competitive compensation
-Paid time off (vacation, holidays, and sick leave)
-Flexible work arrangements (hybrid or remote options where applicable)
-Professional development support (e.g., conference attendance, training)
-401k, Bonus, Equity, Healthcare (Medical, Dental, Vision)
-Opportunity to work at the forefront of cancer research in a mission-driven startup environment
Requirements
Qualifications:
-PhD in Pharmacokinetics, Pharmaceutical Sciences, Medicinal Chemistry, Analytical Chemistry, or related discipline with 3+ years of relevant industry experience, or MSc with 5+ years of pharmaceutical and biotechnology experience
-Strong foundation in DMPK, ADME, and pharmacokinetics for small-molecule drug discovery, development and clinical
-Experience designing and interpreting in vivo PK/ADME studies, as well drug metabolism profile
-Familiarity with PK/PD modeling tools (e.g., Phoenix, MATLAB, R) is a plus
-Experience working with CROs and managing outsourced studies
-Excellent data analysis, problem-solving, and communication skills
-Comfortable operating in a fast-paced, highly collaborative startup environment
-Self-motivated, adaptable, and eager to take ownership of projects
